Environmental Testing Standards
Aqua Solutions COD Standard 1,000 ppm Certified Solution (500ML)
COD Standard 1,000 ppm Certified Solution (500ML)
Apexbio Technology LLC Sulfadoxine 2447-57-6 10g
Sulfadoxine (CAS 2447-57-6) is a small-molecule inhibitor targeting dihydropteroate synthase It is designed to competitively inhibit this enzyme thereby disrupting folate biosynthesis in Plasmodium parasites Sulfadoxine exerts its biological activity primarily through inhibition of dihydropteroate synthase mediated folate synthesis In cell-based studies sulfadoxine demonstrates inhibitory activity against human immunodeficiency virus (HIV) replication within peripheral blood mononuclear cells (PBMCs) with an IC50 value in the micromolar range Based on these pharmacological properties sulfadoxine holds research potential in antimalarial drug investigation parasite metabolic pathway studies pathogen susceptibility assays antiviral pharmacological experiments and investigations of host-pathogen interactions and viral replication mechanisms
Apexbio Technology LLC Naproxen Sodium 26159-34-2 10g
Naproxen sodium (CAS 26159-34-2) is a non-selective cyclooxygenase (COX) inhibitor that suppresses both COX-1 and COX-2 activity In vitro it exhibits IC50 values of 35 48 mol/L for COX-1 and 64 62 mol/L for COX-2 Naproxen sodium influences satellite cell biology by affecting proliferation fusion and differentiation particularly when both COX-1 and COX-2 are inhibited In HCA-7 colon cancer cells naproxen reduces cell viability with an IC50 of 1 45 0 07 M after 48-hour exposure Clinically repeated dosing in volunteers results in substantial inhibition of COX isoforms while research in menstrual migraine models shows significant reductions in headache parameters
Apexbio Technology LLC Solvent Blue 35 17354-14-2 10g
Solvent Blue 35 (CAS 17354-14-2) is a synthetic lipophilic dye used for selective staining of triglycerides in animal tissue samples It integrates into nonpolar solvents such as alcohols and hydrocarbons to facilitate visualization of neutral lipid components within histological techniques Solvent Blue 35 is applied in laboratory settings for analyzing lipid accumulation distribution and metabolism Based on these properties Solvent Blue 35 holds research potential in the investigation of physiological and pathological lipid storage including fatty liver disease metabolic disorders obesity and related biomedical studies of lipid metabolic pathways
Apexbio Technology LLC L-Phenylephrine 59-42-7 10g
L-Phenylephrine (CAS 59-42-7) is a selective agonist of the adrenergic 1A receptor exhibiting a Ki of 1 4 M with markedly lower affinity for 1B (Ki 23 9 M) and 1C (Ki 47 8 M) subtypes In vitro L-Phenylephrine has been shown to reduce apoptosis in neonatal rat cardiomyocytes following hypoxia and serum deprivation and to stimulate proliferation in neural progenitor cells It also increases the cross-sectional area and modulates gene expression in rat neonatal cardiomyocytes In vivo local administration in rats induces cutaneous anesthesia through 1-adrenergic receptor activation and clinical data suggest oral administration reduces nasal airway resistance These properties make L-Phenylephrine a valuable tool for studying 1A-adrenergic receptor-mediated cellular responses
Apexbio Technology LLC Spermine 71-44-3 10g
Spermine (71-44-3) is a small-molecule inhibitor targeting inward rectifier potassium (K ) channels It is designed to block channel conductance thereby modulating cellular excitability and resting membrane potential Spermine exerts its biological activity primarily through direct inhibition of K channel function In experimental studies spermine demonstrates strong channel inhibition with an IC50 value of approximately 31 nM at a membrane potential of 50 mV in cloned IRK1 potassium channels Based on these pharmacological properties spermine holds research potential in potassium channel modulation neuronal excitability studies and investigation of neurological conditions associated with altered glutamatergic signaling and polyamine metabolism
Apexbio Technology LLC (±)-Baclofen 1134-47-0 10g
( )-Baclofen (CAS 1134-47-0) is a selective agonist of the -aminobutyric acid type B (GABAB) receptor a G protein-coupled receptor involved in inhibitory neurotransmission Exhibiting an IC50 of 200 nM ( )-baclofen induces skeletal muscle relaxation and reduces spasticity by activating GABAB-mediated signaling pathways In cellular studies ( )-baclofen inhibits the proliferation of human hepatocellular carcinoma (HCC) cells in a dose-dependent manner induces G0/G1 cell cycle arrest and modulates intracellular cAMP and p21WAF1 expression In vivo it suppresses tumor growth in HCC xenograft models without evident toxicity ( )-Baclofen is thus valuable for investigating GABAB-mediated mechanisms in cancer and neuropharmacology
Apexbio Technology LLC Trimethoprim 738-70-5 10g
Trimethoprim (CAS 738-70-5) is a small-molecule inhibitor targeting bacterial dihydrofolate reductase (DHFR) It is designed to selectively inhibit DHFR thereby disrupting folate metabolism and nucleic acid synthesis in bacteria Trimethoprim exerts its biological activity primarily through competitive inhibition of bacterial DHFR In experimental studies trimethoprim demonstrates inhibitory activity with IC50 values ranging from approximately 5 to 15 nM against bacterial DHFR enzymes Based on these pharmacological properties trimethoprim holds research potential in studies of microbiology urinary tract infections bacterial metabolism folate biosynthesis antimicrobial resistance and in the pharmacological profiling of antibacterial agents
Cambridge Isotope Laboratories Fortified Cod Liver Oil Reference Material 10 g
Fortified Cod Liver Oil Reference Material 10 g
Apexbio Technology LLC Clofibrate 637-07-0 10g
Clofibrate (CAS 637-07-0) is a small-molecule agonist targeting peroxisome proliferator-activated receptor alpha (PPAR-alpha) It is designed to activate PPAR-alpha thereby regulating lipid and lipoprotein metabolism pathways Clofibrate exerts its biological activity primarily through PPAR-alpha activation leading to enhanced peroxisome proliferation and fatty acid oxidation In both human and mouse models Clofibrate demonstrates agonist activity with EC50 values of 55 M and 500 M respectively Based on these pharmacological properties Clofibrate holds research potential in investigating lipid metabolism triglyceride regulation and the roles of PPAR-alpha signaling in hyperlipidemia and related metabolic disorders
Apexbio Technology LLC Betaine hydrochloride 590-46-5 10g
Betaine hydrochloride (CAS 590-46-5) is a quaternary ammonium compound that serves as a methyl group donor in cellular metabolism notably participating in the methionine-homocysteine cycle to modulate homocysteine levels Extracted from natural sources such as wolfberry and Achyranthes this molecule is soluble in water and ethanol facilitating its use in various assay systems Betaine hydrochloride is frequently employed in biomedical research to investigate metabolic regulation methylation processes and osmoregulatory mechanisms The compound should be stored tightly sealed in cool dry conditions to maintain stability for experimental applications
Hach Company COD Standard Solution, 300 mg/L as COD (NIST), 500 mL
For accuracy checks in Chemical Oxygen Demand (COD) determinations. 500 mL bottle
Apexbio Technology LLC sodium fluoride 10000mg
Sodium fluoride is an inorganic compound widely utilized in biomedical research for its inhibitory action on enzymes involved in cellular metabolism particularly enolase within the glycolytic pathway By inhibiting glycolytic activity sodium fluoride disrupts ATP production making it a valuable tool for assessing metabolic processes in vitro It is commonly employed to prevent glycolysis in blood samples for biochemical assays and in studies investigating metabolic regulation cellular energetics and mechanisms of fluoride toxicity Sodium fluoride s modulation of metabolic enzymes supports its use in mechanistic studies of cell physiology and metabolic control